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Alpelisib monotherapy in PIK3ca-mutated efficacy on triple-negative metastatic breast cancer in subsequent lines: a case report

MOJ Surgery
Moisés de Sousa Martins Lopes, Emili Galvani de Menezes Ayoub, Flávia Viecili Tarcha, Taciana Sousa Mutão

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We report a case of a female patient with breast cancer, emphasizing the importance of a new biopsy of the metastases with the evolution of the disease and the response to alpelisib monotherapy in subsequent lines for triple negative breast cancer (TNBC) with PI3K gene mutation, histological subtype historically with poor outcome and limited treatment options.


Triple-negative breast cancer, PI3KCA gene mutation