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Value of serum calcium in preeclamptic Sudanese women

MOJ Women's Health
Salmma MA Abdulla,1 Samah Karoum,2 Sahar Fadul,1 AbulGasim Karoum,2 Mihad Mobark,3 Zohal AA Abdalla,4 Mohammed AS Mohammed,5 Mosab Nouraldein Mohammed Hamad,6 Mamoun Magzoub7


Background:Preeclampsia is a pregnancy-related hypertensive disorder occurring in the second half of the pregnancy and is one of the major causes of maternal and fetal morbidity and mortality. Though the etiology is obscure, recent studies indicate that the levels of serum calcium may play a role in the development of preeclampsia. The aim of this study to find out the relationship of serum calcium in preeclamptic pregnancies compared to normal pregnancies.

Methods:This was a case control study carried out at Bahari Hospital which included 100 women with preeclampsia in the third trimester of pregnancy as a study group and 100 healthy pregnant women in their third trimester of pregnancy as a control group with similar maternal and gestational age. The concentration of the corrected total serum calcium was measured by measuring total serum calcium and serum albumin using a spectrophotometric method. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 23.

Results:The age of the participants was (18-45) years old, with gestational age ranging from (34-36) weeks, there was no significant difference between the two groups in their age, gestational age, with p value (0.5) and (0.2) respectively. Plasma calcium level was lower in preeclamptic women as compared to healthy control subject, the mean value of plasma calcium levels were (7.1±0.8) mg/dl and (9.6±0.4) mg/dl, in study and control groups respectively, the difference in the mean were statistically significant with p value (0.001).

Conclusion:Hypocalcaemia related to preeclampsia supports the hypothesis that alternation in the total serum calcium levels may be involved in the possible pathogenesis of preeclampsia.


eclamsia, preeclampsia, calcium