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Study on prevalence, clinical profile & drug use pattern of nephrotic syndrome in children aged between 1-12 years admitted in a tertiary care hospital


Journal of Pediatrics & Neonatal Care
  Siyamala G R S, Dhanalakshmi P, Kaviya V, Mahendravarman P, Sucindar M

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Abstract

Nephrotic syndrome is a common pediatric kidney disease characterized by protein leakage from the blood into urine through damaged glomeruli. It is a disease of glomerular filtration barrier failure, manifesting with severe proteinuria leading to hypoalbuminemia, hypercholesterolemia and generalized edema. The main objective of the study is to know the prevalence and clinical profile of children having nephrotic syndrome and to study the drug use pattern followed for the same. This is a retrospective cross sectional observational study. Children aged between 1-12 years and those who are steroid sensitive including both single episode and relapse is the inclusion criteria and those who are steroid resistant and congenital nephrotic syndrome are excluded in this study. This study is conducted by collecting the case sheets from the medical records department and analyzed using suitable statistical tools. This study concludes that the prevalence of nephrotic syndrome is 30% higher in males compared to females. Higher prevalence of about 41.6% of nephrotic syndrome was reported in age group of 6 to 12 years. Facial puffiness was the most common symptoms observed in nearly 94% of the cases. Prednisolone, a corticosteroid is the first choice of specific drug given for the patients with nephrotic syndrome accounting for about 73% of cases. Regimen based on body weight Mg/kg/day regimen was the mostly prescribed regimen (85.71%) compared to regimen based on body surface area mg/m2/day of prednisolone in both single episode and relapse cases of nephrotic syndrome.

Keywords

nephrotic syndrome, glomerular filtration, proteinuria, edema, prednisolone, steroid sensitive, frequent relapse

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