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Fertility potentials of five medicinal plants in the treatment of infertility caused by polycystic ovarian syndrome in female wistar albino rats

International Journal of Complementary & Alternative Medicine
Ozioko Eucharia N,1 Ajibade GA,1  Vantsawa PA,2  Appah J2

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Polycystic ovarian syndrome cause infertility in females within childbearing age, Patient with Polycystic ovarian syndrome (PCOS) go through the stress of taking serial medication for years including various medical procedures which are quite traumatic and painful. PCOS was induce in the experimental animals by administering 1mg/kg per body weight of letrozole for twenty one days. After 21days oral administration of letrozole to the experimental animal Blood samples were collected for Glucose and Lipid profile. Serum Progesterone, Estradiol, Testosterone, Luteinizing and Follicle stimulating hormones were measured with enzyme – linked immunosorbent Assay Kit. After the confirmation of the establishment of PCOS, the following plant extracts were administered at 300mg/kg and 100mg/kg per body weight for 15days to different groups of animals in separate cages: Trigonella foenum graecum, Sesamum indicum, Glycine max, Glycyrrhiza glabra and Lepidium meyenii. The result shows T. feonum graecum and G. glabra effectively reduced insulin resistance by reducing the glucose level from 7.60mmol/L in the PCOS group to 5.50mmol/L in T. feonum graecum and 5.23mmol/L in G glabra. Increased in lipid profile caused by polycycstic ovarian syndrome as seen in the PCOS group was reduced effectively byS. indicum and G. glabra. More so, effective control of increased androgen level and hirsitism was shown by T. feonum graenum and L. meyenii  by reducing  the testosterone level from 34.4ng/ml in the PCOS group to 5.33ng/ml in T. feonum graecum and 7.10ng/ml in L meyenii. Ability to increase follicle stimulating hormone was shown in S indicum, T graecum, G max, and G glabra, whereas the ability to ovulate, go through a successful gestation period, and deliver live babies was seen in S indicum and T greacum, this could be attributed to the high flavoniod (phytoestrogens) seen in the two plant extracts. The best of all the plants extracts is the extract of T graenum because of the continuous fertility recorded in this group and also their none toxic effect on the vital body organs.


polycystic ovarian syndrome, infertility, testosterone, follicle stimulating hormone, luteinizing hormone, progesterone