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The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin!!!

Journal of Pediatrics & Neonatal Care
Georges Pius Kamsu Moyo, Suzanne Sap Ngo Um, Hubert Désiré Mbassi Awa, Evelyn Mah, Andreas Chiabi, Paul Olivier Koki Ndombo

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Urinary tract infection is one of the most common type of infections in neonates, with
the capacity to induce neonatal jaundice which is another major emergency in neonates.
However, the pathophysiology of this comorbidity is still poorly described in neonatology
and the clinical implications insufficiently illustrated. The aim of this review is to contribute
to shed more light over this issue in order to improve understanding and orientate therapeutic
interventions. In this piece of work, we did a critical study of recent and pertinent articles
on the topic available online. This enabled us to make a synthesis of current classifications
of neonatal jaundice, with epidemiological, etiological and pathophysiological aspects of
the comorbidity with urosepsis being discussed. We conclude with consequent therapeutic


Jaundice, neonatal sepsis, urinary tract infection