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Presentation of multiple myeloma with absolute lymphocytosis? Coexistence of CLL & multiple myeloma

Hematology & Transfusion International Journal
Noorulain Fareed,Noor Muhammad Somroo,Ghulam Fatima2

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The presence of a chronic lymphocytic leukemia and multiple myeloma in a single patient is very rare. Multiple myeloma is a plasma cell disorder, whereas CLL (Chronic Lymphocytic Leukemia) is the mature B-cell lymphocytes disorder. We described a 50 year-old man who presented with fatigue and lethargy of 1 month duration. He was found to be anemic, with lymphocytosis, decreased renal function, high calcium level, and conspicuous M-Spike on serum electrophoresis. Furthermore, peripheral smear & bone marrow biopsy demonstrated two distinct hematological malignancies on morphological basis.


chronic lymphocytic leukemia, coexistent, multiple myeloma