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Autosomal –dominant epidermodysplasia verruciformisun satisfactorily treated with ingenol mebutate: a case report 


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Abstract

Background:Epidermodysplasia verruciformis(EV) is a rare, usually autosomal-recessive inherited disorder characterised by development of flat wartsortinea versicolor-like lesions on sun exposed area caused byspecific human papillomavirusis (HPVs). Several nonsurgical treatment modalities were tried with temporary results, but successful treatment of EV with ingenol mebutate (Picato) has been reported recently. In this case, autosomal-dominant EV unsatisfactorily treated with ingenol mebutate is shown.
Case: A 58-year-old woman with EV was unsuccessfully treated with traditional therapeutical modalities. Ingenol mebutate(0,5%) was administered for 2 days and a significant improvement in lesion reduction was achieved. However, after 2 months there was a recurrence with the appearance of new lesions and an increase of existing ones.
Conclusion:Thisreport is another confirmation that EV remains a therapeutic challenge.
Background:Epidermodysplasia verruciformis(EV) is a rare, usually autosomal-recessive inherited disorder characterised by development of flat wartsortinea versicolor-like lesions on sun exposed area caused byspecific human papillomavirusis (HPVs). Several nonsurgical treatment modalities were tried with temporary results, but successful treatment of EV with ingenol mebutate (Picato) has been reported recently. In this case, autosomal-dominant EV unsatisfactorily treated with ingenol mebutate is shown.
Case: A 58-year-old woman with EV was unsuccessfully treated with traditional therapeutical modalities. Ingenol mebutate(0,5%) was administered for 2 days and a significant improvement in lesion reduction was achieved. However, after 2 months there was a recurrence with the appearance of new lesions and an increase of existing ones.
Conclusion:Thisreport is another confirmation that EV remains a therapeutic challenge.
 

Keywords

epidermodysplasia verruciformis, human papilloma viruses, ingenol mebutate, autosomal- dominant EV, histologically diagnosed

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