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Association between functional neurometry test results and blood biomarkers indicative of anaemia, subclinical inflammation, and endothelial dysfunction


International Journal of Complementary & Alternative Medicine
Renata de Melo Guerra Ribas,1 Valdenilson Ribeiro Ribas,1 Diélita Carla Lopes de Oliveira,1 Marcelo Tavares Viana,1 Joyce Gomes de Moraes,1 Hugo André de Lima Martins,1 Carlos Frederico de Oliveira Alves,1 Nery Adamy Neto, Murilo Tolêdo Calafange,2 Clenes de Oliveira Mendes Calafange,2 Ana Elisa Toscano,2 Raul Manhães de Castro2

Abstract

Introduction: Functional neurometry-FN assesses the functioning of the autonomic nervous system.

Objective: The association between FN test results and the biomarkers of anaemia, subclinical inflammation-SI and endothelial dysfunction-ED was evaluated.

Method: 412 male patients aged between 18-50 years were evaluated by FN and Laboratory Testing. Groups: control (CONT, n=194) and dysfunctional (DYSF, n=218).FN categories: Anxiety Control-(AC) ≥75%, Baroreflex Index-(BRI) ≥90%, Hemodynamic-(HD) ≤10% and Physiological response-(PR) =31.5o-32.5o, expressed in Median/(Minimum-Maximum). Biomarkers: red blood cells-RBC, haemoglobin, haematocrit, mean corpuscular volume-MCV; mean corpuscular haemoglobin-MCH; mean corpuscular haemoglobin concentration-MCHC; red cell distribution width-RDW; total leukocytes-TL, ferritin, transferrin saturation-TS, B12, homocysteine, C-reactive protein-CRP; fibrinogen; 25-hydroxy-vitamin-D3; apolipoprotein A1-Apo-A1; apolipoprotein B-Apo-B; glutamic oxalacetic transaminase-GOT; glutamic-pyruvic transaminase-GPT; Gamma GT; 8am cortisol; IgE; total cholesterol-TC; triglycerides-TG, and; high-density lipoprotein-HDL and low-density lipoprotein-LDL, expressed in frequency-[percentage] and analysed by the Chi-square test with p≤0.05*.

Results: DYSF presented: AC=24.91/(10.11-69.17), BRI=86.54/(67.33-87.82), HD=17.89/(15.74-24.41), PR=24.98/(22.60-28.60) and higher frequencies of patients with dysfunctional biomarkers: RBC 21/218-[9.63%]; haemoglobins=94/218-[43.12%]; haematocrits=52/218-[23.85%]; MCV=114/218-[52.29%]; RDW=52/218-[23.85%]; ferritin=42/218-[19.27%]; B12=157/218-[72.02%]; homocysteine=135/218-[61.93%]; GPT=53/218-[24.31%]; Gamma-GT=94/218-[43.12%]; cortisol=114/218-[52.29%]; IgE=53/218-[24.31%]; TL=177/218-[81.19%]; CRP=85/218-[38.99%]; fibrinogen=74/218-[33.94%]; 25-hydroxy-vitamin-D3=138/218-[63.30%]; TC=125/218-[57.34%]; TG=63/218-[28.90%]; HDL=35/218-[16.06%]; LDL=65/218-[29.82%]; TL/HDL(>3.3)=138/218-[63.30%], TG/HDL(>2.5)=138/218-[63.30%], LDL/HDL(>2.3)=42/218-[19.27%] and Apo-B/Apo-A1(>0.69)=95/218-[63,30%] ratios, compared to controls: AC=75.88/(72.05-85.00), BRI=92.80/(89.00-95.98), HD=10.00/(09.00-10.00), PR=32.25/(29.00-33.73), haemoglobins=13/194-[6.70%], haematocrits=5/194-[2.58%], MCV=14/194-[7.22%], RDW=2/194-[1.03%]; ferritin=5/194-[2.58%]; B12=12/194-[6.19%]; homocysteine=4/194-[2.06%]; GPT=14/194-[7.22%]; Gamma-GT=17/194-[8.76%]; cortisol=21/194-[10.82%]; IgE=4/194-[2.06%]; TL=21/194-[10.82%]; CRP=6/194-[3.09%]; fibrinogen=4/194-[2.06%]; 25-hydroxy-vitamin-D3=9/194-[4.64%)]; TC=22/194-[11.34%]; TG=21/194-[28.90%]; HDL=10/194-[5.15%]; LDL=14/194-[7.22%], TC/HDL=14/194-[7.22%], TG/HDL=6/194-[3.09%], LDL/HDL=5/194-[2.58%] and Apo-B/Apo-A1=22/194-[11.34%].

Conclusion: This study found a significant association between FN test results and biomarkers indicative of anaemia, SI and ED.    

Keywords

functional neurometry, biomarkers, anaemia, subclinical inflammation, endothelial dysfunction

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