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Cohort study on congenital cytomegalovirus seroprevalence and its association with neonatal cholestasis

International Journal of Pregnancy & Child Birth
Nagaraj Perumal,1 Rajeev Kumar,1 Deepti Chaurasia,1 Jyostna Srivastava2

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Cytomegalovirus (CMV) is a frequent causative agent of congenital infection in newborns and results in serious morbidity and mortality. CMV viral infection also have an important role in the pathogenesis of neonatal cholestasis (NC) and related clinical outcomes. To determine the incidence of congenital CMV infection and its association with NC cases, this study included a total of 234 infants who were presented with clinical symptoms suggestive of congenital CMV infection. Serum samples were collected and screened for the presence of serological markers to CMV. Of the 234 samples tested, 15% showed the presence of CMV IgM, among whom 54 had neonatal cholestasis. CMV infection in patients with neonatal cholestasis was found to be 21%. The presence of serological markers to CMV in the congenital infection and in neonatal cholestasis cases strongly suggests their association with this disorder.


cytomegalovirus, congenital viral infection, infants, neonatal cholestasis