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Acromegaly and testicular seminoma: a rare association

Endocrinology & Metabolism International Journal
Abainou L,1 Eljadi H,1 Idrissi A,1 Meftah A,1 Essadi I,2 Akhaddar A,3 Baizri H1

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Context : Acromegaly is a chronic disease characterized by sustained elevation of circulating growth hormone and insulin-like growth factor-I (IGF-I).Epidemiological studies reported higher incidence of neoplasms in acromegalic patients especially colorectal and thyroid neoplasms. We report the case of a rare association of acromegaly to a testicular seminoma that deserves to be discussed.
Case description: A 49-year-old male, who was treated for testicular seminoma, during the follow-up, acromegaly, was suspected because of typical acromegalic features, diagnosis was confirmed by elevated IGF-1 andpresence of pituitary adenoma showed by MRI.
Conclusion: acromegalic patients are at an increased risk of developing neoplasms. Therefore, the clinician must have the reflex to think to look for features of acromegaly in patients with cancer as the case of our patient.


acromegaly, testicular seminoma, IGF1