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Prevailing approaches in chronic liver disease hemostasis

Hematology & Transfusion International Journal
Dragica Vucelic,1 Nikica Grubor1,2

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Based on the emerging knowledge of the complexity and the flexibility of the systems involved in maintaing hemostasis in health and in disease, the tenet of coagulation in cirrhosis has undergone significant revision in the last 18 years. Recent attention has focused on global assays to better guide therapeutic decisions tailored to each patient’s clinical and hemostatic status. This new concept generates consequences in therapeutic interventions whether as prophylaxis or as salvage for acute events. There is yet no optimal management strategies for the critical clinical outcomes (bleeding or thrombosis) in cirrhotics neither as prophylaxis nor as therapy


cirrhosis, hemostasis, global assays, transfusion medicine