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Covid-19 and endocrinology – intersections: a review of current knowledge on physiopathological associations

Endocrinology & Metabolism International Journal
Lucas Ribeiro dos Santos,1 Ricardo Baer Filho,2 Thais Amanda Frank de Almeida Alves,2 Matheus Budahazi Jardine,2 Márcio Luís Duarte3


Introduction: The coronavirus-19 pandemic has reached historic dissemination, with a huge impact on physical, social and psychological well-being; understanding the pathophysiology of the disease is extremely important, as it can lead to effective therapy formulations.

Objective: In this review, we will explore the current evidence surrounding the interactions of endocrine conditions and possible treatment targets. Methods: we reviewed the Medline, EMBASE and LiLACS databases using the keywords “COVID-19” or “SARS-CoV-2”, crossing them with the keywords “Obesity”, “Diabetes Mellitus”, “Vitamin D”, “ Estradiol ”,“ Testosterone ”,“ Male ”and“ Female ”; we will describe the results found in a narrative way. Results: The association of diabetes mellitus, obesity and worse prognosis of people infected with the SARS-CoV-2 virus, as well as the gender dimorphism of severity and the role of vitamin D deficiency will all be described.

Conclusion: There is a riddle involving SARS-CoV-2 infection, intrinsic risk factors of the host, as well as the immune response to the infection, which is still in the solution phase; a better understanding of such mechanisms can lead to the development of highly effective treatment, as well as policies of social isolation.


endocrinology, COVID-19, obesity, Ddiabetes mellitus, vitamin D