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Efficacy of surface modification by layer-by-layer loading for drug delivery


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Abstract

Controlled drug release can improve efficacy and decrease toxicity by keeping drug concentration at the optimal level. It can also limit the required number of drugs to be administered, thereby improving the compliance of the patient. Layer by layer (LbL) drug delivery systems, for its features; bendability, functionalizability, cost and case of development/production has dominated research in controlled release systems. Some drugs cause serious side effect to other parts of the body. The use of such drugs is encouraged if it can only get to a target area by distribution control. This distribution control can be achieved by either implant at the target site or polymeric surface modification (LbL) that is capable of releasing drug to the site of action. Beside controlling of drug release, it also increases efficacy by preserving the active form of the drug within its protective microenvironment. This work presents the efficacy of LbL as controlled drug delivery.

Keywords

controlled drug delivery, degradation, LbL, deposition, nanocomposites, polyelectrolyte

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