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New markers for the detection of polycystic ovary syndrome 

Obstetrics & Gynecology International Journal
Elham Sharif, Mariam Alwakeel


Polycystic Ovary Syndrome (PCOS) is a highly prevalent, complex genetic disorder of the endocrine system in women. Alterations that occur in women with PCOS can be due to several predisposing factors; among these contributors are genetic and epigenetic variations. Environmental factors play a weaker role, mainly in worsening insulin resistance. Enzyme, protein and genetic markers can depend as a biochemical diagnosis of PCOs. The genetic markers have been identified to be related to PCOS wasn’t useful for early diagnosis, which can only be used to confirm PCOS in patients already exhibiting the definitive symptoms. Protein and enzyme markers are commonly used for prognosis and monitoring the patient to prevent the development of the complications of PCOS. Proteins of the adipose tissue have been found to be greatly related to insulin resistance and the development of PCOS. The nature of enzymes and proteins of instability and easily degradable have prevented sufficient research from being carried out on them. Therefore, the diagnosis of PCOS relies on the analysis of multiple factors.


Ovary syndrome, Biochemical diagnosis, Fertility, Ovulation, Reproduction, Polycystic ovary syndrome, Insulin receptor substrate, Sex hormone-binding globulin, Tumor necrosis factor, Interleukin-6, Luteinizing hormone, Follicle stimulating hormone, Gonadotropin-releasing hormone, Anti-müllerian, Bsphenol A