Abstract

Objective: Compare the dose received with the estimated theoretical dose, considering the body mass index and serum creatinine concentration of each patient. Method: Observational, retrospective, descriptive study on carboplatin dosing based on the estimation of renal function and the area under the target curve in 74 patients treated with cycles of chemotherapy that included carboplatin in the oncohematology day hospital. Results: The analysis revealed that in 72% of the patients, the creatinine values used to calculate the dose were higher than the actual values, resulting in under-dosing in most patients. When comparing the estimated theoretical dose and the administered dose, an intraclass correlation coefficient (ICC) of 0.929 (95% CI: 0.774 - 0.970) was obtained in normal weight patients and 0.819 (95% CI: 0.353 - 0.930) in overweight or obese patients. It was observed that the discrepancy between theoretical and prescribed doses increased with in-creasing theoretical dose of carboplatin. Conclusions: The findings of this study underscore the importance of using actual serum creatinine values in the calculation of carboplatin dose as a key measure to minimize under--dosing in carboplatin administration.

Keywords

carboplatin, serum creatinine, body mass index, calvert