Abstract

Mosquito, Aedes aegypti is a most critical public health problem in a lot of countries, and controlling of mosquito is a biggest challenge in the control programme. There is a need for decision biological active molecules to control mosquito in order to prevent dengue virus transmission. To assess is isolation of major phyto-compound (MPC) Phenol, 2-methyl-5-(1-methylethyl) and molecular docking of plant, Wedelia calendulacea (W. calendulacea) against Ae. aegypti. In the ovicidal activity, 100% mortality was extracted by fraction 6 tested at 10 ppm against Ae. aegypti. In mass spectra analysis, a total of nineteen compounds was identified in the methanolic extract composition, the main component was Phenol, 2-methyl-5-(1-methylethyl). Molecular docking studies performed with the mosquito juvenile hormone-binding protein (MJHP) demonstrated that the Phenol, 2-methyl-5-(1-methylethyl) compound towards the one enzyme. The findings thus reveal that the medicinal plant compound can be a better possible to accessible chemicals to control mosquitoes.

Keywords

major phyto-compound, methanolic extract, aedes aegypti, wedelia calendulacea, molecular docking, mosquito juvenile hormone-binding protein