Abstract

Gastric cancer (GC) continues to be a major health problem worldwide. This article discusses the role of the miRNA-200 family, especially miR-200c, in GC. The miR-200 family plays essential managing role in processes including epithelial-mesenchymal transition (EMT), cell proliferation, apoptosis, and metastasis. miR-200c can reduce cellular invasion and increase the susceptibility of cancer cells to chemotherapeutic drugs by increasing E-cadherin levels. Several studies have shown that low expression of miR- 200c in GC negatively affects the prognosis of the disease and is associated with resistance to chemotherapy. It has also been indicated that miR-200c has great potential as a biomarker for early diagnosis of GC and a therapeutic target for enhancing response to chemotherapy. According to the current findings, further studies needed to understand the role of miR-200c in GC.

Keywords

miRNA-200 family, gastric cancer