Stevens-Johnson Syndrome secondary to nivolumab in a patient with mixed cell variety classical Hodgkin Lymphoma
- Hematology & Transfusion International Journal
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Santiago-Benítez Mary Jose,1López-Navarro Omar,2 Arias-Ruiz Luis Felipe,3 Gatica-Torres Michelle,4 Puentes-López José Alfredo,1 Fernández- Ferreira Ricardo,5 AguirreOrozco María Camila,1 Cervera Ceballos Eduardo2
Abstract
The immune checkpoint inhibitors (ICIs) nivolumab and pembrolizumab are some of the principal treatment options for relapsed or refractory classic Hodgkin lymphoma. However, immunotherapy has been related to dermatological adverse events (DAEs) and could lead to discontinuation of cancer treatment in severe cases. DAEs encompass entities such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), SJS/TEN-like reactions, drug reaction with eosinophilia and systemic symptoms (DRESS). We reported a case of a 46-year-old- female with classic mixed cellularity Hodgkin lymphoma, Lugano IV, who underwent a hematopoietic cell transplant and subsequent relapse, currently with Stevens Johnson Syndrome secondary to nivolumab.
Keywords
cutaneous toxicity, oncodermatology, toxicities from immunotherapy, Stevens-Johnson Syndrome, nivolumab
