Abstract

Gestational hyperglycemia, characterized by elevated blood glucose levels during pregnancy, poses significant risks to fetal development, particularly in relation to neural tube defects (NTDs) and other neurological disorders. This overview synthesizes findings from literature to explore the pathophysiological mechanisms by which maternal hyperglycemia influences fetal neurodevelopment. The review focuses on studies that demonstrate how elevated maternal glucose levels lead to fetal hyperinsulinemia, oxidative stress, and impaired placental function, thereby contributing to the risk of congenital anomalies. Various methods where use to assess maternal glucose levels, fetal development, and longterm neurological outcomes, multiple findings emphasize the importance of monitoring and managing maternal blood glucose levels to mitigate risks associated with gestational hyperglycemia. Moreover, the discussion highlights the potential benefits of dietary modifications and early screening for gestational diabetes, underlining the necessity of comprehensive prenatal care, conclusions drawn from this overview stress the need for increased awareness among healthcare providers regarding the implications of gestational hyperglycemia and the implementation of effective intervention strategies to improve maternal and fetal health outcomes. By addressing the complex relationship between maternal glucose control and fetal neurological development, this overview aims to inform future research and clinical practices that prioritize the health and well-being of both mothers and their children

Keywords

glucose, children