Abstract

Heartburn is the most common symptom presented by patients in clinical practice. Causes of heartburn ranging from cardiac origine (heart attach) to acid reflux. Different acid suppressing agents like antacids, H2blockers, PPIs (Proton pump inhibitors) are commonly used. Alginate-based raft-forming products have been used for many years in the management of heartburn and acid reflux disorders and are widely available worldwide. They are commonly used to alleviate symptoms of acid reflux disorders, working through a mechanism distinct from conventional antacids. In the presence of stomach acid, alginates form a gel. These formulations typically include sodium or potassium bicarbonate, which, when exposed to gastric acid, produces carbon dioxide. This gas is trapped within the gel, transforming it into a foam that floats on the stomach contents, much like a raft on water. The strength of the alginate raft depends on various factors, including the amount of carbon dioxide produced and trapped, the molecular structure of the alginate, and the presence of aluminum or calcium in the antacid components. Raft formation happens quickly, usually within seconds of ingestion and offer longer-lasting relief compared to traditional antacids. Optimal benefit of alginate is achieved when taken following a meal. Alginate-based raftforming products are also used to manage reflux symptoms in infants, children, pregnant and breast-feeding women. Their unique, non-systemic mode of action provides both fast and long-lasting relief from heartburn, ensuring their continued role in treating such conditions.

Keywords

Acid reflux, Alginate, GERD, heartburn