Abstract

This case report presents transient periorbital papule formation following type I collagen injections in three female patients aged 38-40 years, administered in the lower eyelid region for periorbital rejuvenation. Intradermal collagen injections, while promising for enhancing periorbital skin quality, carry a risk of localized reactions due to the region’s sensitivity. The patients reported non-painful, firm papules within 5-7 days post-procedure. High-resolution ultrasound confirmed hypoechoic collagen deposits adhering to the dermis, with histological examination in one patient revealing intradermal collagen clusters without surrounding inflammation. Two patients received PRP therapy and at-home massage, while the third was monitored remotely, showing spontaneous resolution within four weeks. Findings indicate that type I collagen injections can lead to transient papules, which resolve without visible scarring, supporting a favorable safety profile for this aesthetic intervention. Further studies are recommended to refine techniques and establish standardized protocols for periorbital collagen injections.

Keywords

collagen injections, collagen type I injections, periorbital rejuvenation