Abstract

Hyperleukocytosis is defined as a total leukocyte count of more than 100*103/mm3, which usually occurs in leukemia, myeloproliferative disorders and leukocyte adhesion defects. It is a rare entity in neonates and is associated with poor outcome. We report a non-malignant case of hyperleukocytosis in a preterm baby with culture negative sepsis and a history of exposure to intrauterine steroids. We highlight the significance of morphological changes in peripheral blood smears which help in early diagnosis and prompt treatment thereby reducing the morbidity and mortality associated with it.

Keywords

Dohle bodies, hyperleukocytosis, neonate, peripheral blood smear, toxic granules