Abstract

Chronic post-traumatic encephalopathy is a neurodegenerative disease resulting from the accumulation of numerous craniocerebral traumas, for which there is no definitive premortem diagnosis or specific treatment. Risk factors associated with chronic post-traumatic encephalopathy include: exposure to contact sports, the presence of apolipoprotein E4, and advanced age. Histopathological, although it shares certain characteristics with Alzheimer’s disease, it has a more specific presentation (deposition of phosphorylated tau protein in the form of neurofibrillary tangles, associated with an accumulation of neuropil elements, sometimes accompanied by beta-amyloid plaques). Clinically, it is characterized by a slow course that begins with mild cognitive and emotional symptoms, and progresses towards the appearance of parkinsonian symptoms and dementia. Although there are promising diagnostic elements, they are not currently a reality, and the key to managing this disease is prevention and early detection of its first symptoms

Keywords

dementia, encephalopathy, knockout, boxing