External validation of the PRECE nomogram model in a Central America cohort
- Urology & Nephrology Open Access Journal
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Marcos Young R,1 Enrique Aleman F,2 Ivy Tejera,2 Thainys Ortega2
Abstract
Introduction: This is an external validation study of the PRECE prostate cancer nomogram
in a Central American population.
Methods: We present 102 consecutive cases of robotic radical prostatectomy, performed
with preservation of the anterior fascia and we use the PRECE nomogram as a guide to
preserve the prostatic neurovascular pedicles. We compared the predicted extra-capsular
extension from the PRECE nomogram to the final prostatectomy pathology.
Results: Analysis of post-prostatectomy pathological samples revealed that 61% patients
had pT2; 27% had a pT3a and 12% had a pT3b, respectively
The ROC curve for the PRECE nomogram at one (1) mm showed a model AUC of 0.91
(95% CI), which implies a high agreement with the PRECE nomogram in the prediction of
extraprostatic disease.
Conclusion: This is the first report of external validation of the PRECE nomogram in a
Central American population. PRECE demonstrated high discrimination for the prediction
of extraprostatic disease in an independent Latin American cohort. More external validation
studies, from different geographic settings, are expected to confirm the reliability and
reproducibility of PRECE in other clinical settings.
Keywords
PRECE nomogram, extraprostatic disease
