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A Unique case report of successful pregnancy and delivery after being treated with pioglitazone and glimepiride (in first three months)

International Journal of Pregnancy & Child Birth
Suman Sarkar,1 Kingshuk Bhattacharya,1Ankan Pathak,1 Nirmalya Roy,Nikhil Sonthalia,1 Anindita Bhar,2 Atrayee Dasgupta3


A planned pregnancy (with IVF) in a patient with type 2 diabetes was treated with insulin along with glimepiride and pioglitazone (treated in first three months) from pre-conception stages until the postpartum is reported. She delivered a single viable male child at 33 weeks of gestation due to pregnancy induced hypertension and type 2 diabetes mellitus with no abnormalities. The newborn was healthy without any congenital and other abnormalities. To our belief, this is the first case reporting the use of pioglitazone as well as glimepiride in early pregnancy. It should be noted that both of the drugs are not recommended to be used in pregnancy but we may come across situations where the patient is already exposed to these drugs and not willing to abort pregnancy and this case adds value to the existing body of medical literature in such cases.


diabetes, pioglitazone, glimepiride, insulin, nifedipine