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Antioxidant activity and hepatoprotector effect of Spilanthes leiocarpa DC in rats with induced liver injury


Journal of Analytical & Pharmaceutical Research
Sánchez Chagua Williams, Ramos Aparcana Karen, Chávez Orellana Haydee, Surco-Laos Felipe

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Abstract

The present work studied the phytochemical profile of an aqueous extract of Spilanthes leiocarpa DC. (SLDC) and its antioxidant activity was determined by different methods (FRAP, DPPH and ABTS). The hepatoprotective effect was also evaluated in rats with hepatic damage induced with paracetamol (2 mg / Kg), providing different concentrations of SLDC aqueous extract (100, 200 and 400 mg / Kg) and comparing the results with a commercial hepatoprotective drug, Silymarin. The results of phytochemical screening determined the presence of flavonoids, other secondary metabolites such as triterpenes, steroids, alkaloids and compounds with free amino groups. The aqueous extract of SLDC showed values of antioxidant activity similar to those of the commercial drug Silymarin in the three methods tested. In the tests in rats with hepatic damage induced with acetaminophen, it was observed that, after the ingestion of SLDC, the levels of the enzymes transaminase aspartate aminotransferase (AST) and alanine aminotransferase (ALT) recovered basal values when treated at 400 mg / Kg (69.83±9.44 and 52.43±9.52, for AST and ALT respectively), an effect similar to that observed by treatment with 100 mg / kg of silymarin (72.24±4.22 and 47.18±6.87).

Keywords

spilanthes leiocarpa DC, antioxidant activity, hepatoprotective

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