Abstract

The therapeutic effects of omega-3 fatty acids, which are abundant in some fish oils, have been known since at least the 1950s, when cod liver oil was discovered to be useful in treating conditions such as dermatitis and arthritis. Scientists observed in the 1980s that Eskimos who ate a fish-rich diet had better heart health than their mainland counterparts. Inflammation that is inappropriate, excessive, or uncontrolled contributes to a variety of human disorders. One of the primary pathophysiological pathways causing neuropsychiatric and neurodegenerative illnesses has been identified as inflammation. Despite the fact that inflammation plays a role in many illnesses, there are currently no viable anti-inflammatory therapy methods. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may decrease depressing symptoms and exert anti-inflammatory effects through the production of various n-3 PUFA-derived metabolites, including. Maresin (MaR) and protectin (PD), collectively known as specialized pro-resolving mediators (SPMs), act as potent anti-inflammatory agents. They also control the nervous system, blood pressure, clotting, blood glucose tolerance and inflammatory processes and are favorable in all inflammatory diseases. 

Keywords

inflammation, anti-inflammatory response, n-3 PUFAs and arachidonic acid, NO, nitric oxide, TAC, total antioxidant capacity, PPARs, peroxisome proliferator activated receptors, AA, arachidonic acid, LDL, low-density lipoprotein, DHA, docosahexaenoic acid