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New bioengineering approaches for immunotherapy


Journal of Applied Biotechnology & Bioengineering
Lapina V, Pavich T, Bushuk S, Kalvinkovskaya J

Abstract

New approaches for immunotherapy based on nanodiamond particles have been developed. The possible ways of conjugate synthesis comprising antibody as targeting vector, nanodiamond particles as carrier, chlorine e6 as photosensitizer, have been demonstrated. Spectral-luminescent properties of the conjugates have been studied. It has been shown that the conjugate obtained effectively binds to cells in vitro. It was observed that chlorine e6 immobilized on ND particles reveals its photodynamic activity under illumination and induces death of cells. Based on obtained results, possible advanced therapeutic strategies for novel medicine technologies have been proposed. 

Keywords

antibody, chlorine e6, immunotherapy, nanodiamond particle, photosensitizers

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