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Bioactivities of Launaea taraxacifolia (wild lettuce) on rats induced with osteogenesis inhibitor observed through bone markers


Journal of Analytical & Pharmaceutical Research
Aladenika Yetunde Victoria,1 Akinseye Olanrewaju Roland

Abstract

The bioactivities of plants rely solely on the bioactive compounds contained in such plants. Phytochemical extracts of plants such as Launaea taraxacifolia have shown numerous medicinal properties like osteopromotive, antioxidative, anti-inflammatory, anticancerous and anti-microbial. The main objectives are to study the osteoroporotic effect of aqueous extract of Launaea taraxacifolia on warfarin-induced rats, where change in body weight, CTX-1, Procollagen type 1 N-terminal Propeptide (P1NP) and procollagen Type 1 C-terminal propeptide (P1CP) level represents the observable parameters during the experiment. Twenty-five (25) adult male Wister albino rats with an average weight of (140g-165g) were obtained for the research. After one weeks of acclimatization, osteosporosis was induced in overnight fasted rats by oral administration at a dosage 0.6ml/ 5mg body weight of Warfarin drug. The effect of induction of warfarin on weight loss showed that reduction was observed in body mass between pre and post induction and weight improved after the treatment. The result also revealed the CTX-1 levels of the induced rats increased significantly P ≤ 0.05 compared to the control group. The Procollagen type 1 N-terminal propeptide (P1NP) level of treated animals decreased when compared to the induced group. The result of Procollagen type 1 C-terminal propeptide also revealed a significant decrease P ≤ 0.05 in its level when compared to the control group. These results suggest that Launaea taraxacifolia may be used during bone recovery after injury and that the leaf should be subjected to more extensive medicinal evaluation.

Keywords

bioactive, osteoporosis, procollagen, bone recovery, medicinal

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