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Innovative immune checkpoint inhibitors (ICIs) for cancer treatment: an overview


Abstract

Cancerimmunotherapyhassignificantlyincreasedpatients'chancesofsurvivalandquality of life as compared to earlier standards of care (such as chemotherapy,radiation,andsurgery).Fromthemetastaticstagetotheadjuvantandneoadjuvantsettings in many cancer types, immunotherapy has now firmly established itself asanovelpillarofcancercare.Inthisreviewarticle,weemphasisehowthedevelopment of cancer immunotherapy led to findings that are today consideredbest practises. We also show out the existing drawbacks and restrictions of cancercheckpointimmunotherapyandthewaysinwhichcutting-edgeresearchisattemptingtoaddresstheseissues.

Keywords

cancer, immunotherapy, immune checkpoint inhibitors, tumor microenvironment, immunoscore

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