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The outcome of acute pancreatitis patients with acute kidney injury- Single centre study from North India


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Abstract

Introduction:Acute Pancreatitis (AP) results in 100,000 hospitalizations per year and the incidence of acute pancreatitis ranges from 13 to 45 per 100,000 population-years. Eighty percent of cases of AP are interstitial and mild; the remaining 20% to 30% are necrotizing and severe with hospital mortality rates of 15%.1Acute kidney injury (AKI) is a common serious complication of AP and an important marker of morbidity and mortality in critically ill patients. The prognosis of AP patients with AKI is extremely poor with mortality rates ranging between 25-75%.2,3

Methodology:Study type and design:observational, cross sectional study, single centre study. The main source of data for the study was collected from patients with AP admitted in Department of General Medicine and Gastroenterology department of Santokba Durlabhji Memorial Hospital, Jaipur, India.

Results: AKI was found in 27 out of total 144 study subject resulting in an incidence of 18.75% in our study. Mean age of patients who developed AKI was significantly higher when compared to patients without AKI with significant p value. In our study, we found that high BMI and high SOFA score at admission were risk factors for AKI. Patients of AP with AKI had longer average hospital stay and ICU stay when compared to patients without AKI. We also found high mortality in AP patients who developed AKI had (48.15% Vs 1.71%) as compared to patients of AP without AKI.

Conclusion:From current study we can conclude that, AKI is a serious complication of AP and leads to a poor outcome.

Keywords

AP, acute pancreatitis, AKI, acute kidney injury, SAP, severe acute pancreatitis, CBC, complete blood counts, CKD, chronic kidney disease, NIV, non invasive ventilation, CAD, coronary artery disease, CLD, chronic liver disease, COPD, chronic obstructive pulmonary disease, SOFA, Sequential Organ failure assessment

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