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Dual role of cytokines in tumor microenvironment


Cytokines are immune mediators produced by innate and adaptive immune cells. Cytokines are anti-inflammatory or antitumorigenic or protumorigenic depending on tumor microenvironment. Some of the cytokines such as IL-1β, Il-6,TGF-β involved in tumor progression by activation of transcription factors such as NF-KB,STAT-3,HIf-1α and AP-1. This article briefs about the role of cytokines involved in antitumor and protumor activities.


antitumor cytokines, protumor cytokines, NF-KB