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Immunoinformatic analysis of proteins from DNA replication, repair, recombination, and restriction/modification pathway of Mycobacterium tuberculosis revealed the diagnostic potential of Rv0054 and Rv3644c

Journal of Applied Biotechnology & Bioengineering
Vikas Jha,1 Sathi Maiti,2 Dattatray Sawant,1 Darpan Kaur,1 Sankalp Kasbe,1 Abhishek Kumar,1 Badal Saiya,1 Shloka Shukla,1 Simeen Rumani,1 Mrunmayi Markam1


Mycobacterium tuberculosis being a causative agent of tuberculosis is a powerful pathogen that has evolved to survive within the host. There are certain metabolic pathways that play a vital role in host-pathogen interaction, pathogenicity and virulence which is indicated by the pathophysiology of Mycobacterium tuberculosis (MTB). The pathways involve many proteins that are vital for MTB survival in the host. One such pathway is DNA replication, repair, recombination, and restriction/modification pathway. The study of DNA repair mechanisms in Mycobacterium tuberculosis has progressed more slowly than in other bacteria due to the technological challenges in dealing with a slow-growing pathogen. In this study, by utilizing immunoinformatic analysis & homology modelling approach, the evaluation of the proteins involved in this pathway was carried out which can lead to the discovery of potential drug targets, vaccine candidates as well as various diagnostic markers. 


In-silco, Mycobacterium tuberculosis, homology modelling, diagnostic markers, vaccine candidates