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Effect of delayed luminal carbodhydrate uptake via α-glucosidase inhibition on plasma glycemic parameters and lipid profiles in adult wistar fatty rats

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To determine the effects of delayed luminal glucose uptake on plasma glycemic and lipid profiles, groups of adult male lean and obese+NIDDM Wistar Fatty Rats (n=8 rats/group) were fed nutritionally complete diets where the carbohydrate was provided as cooked cornstarch (CS), sucrose (SU), or the SU diet containing an admixture of the luminal α-glucosidase inhibitor compound acarbose (ACB, 150mg/kg diet) from 22 to 30weeks of age. Measures of body weight, caloric intake, fasting Insulin to glucose (I: G) ratios, and plasma cholesterol (CHOL), triglyceride (TG) and Alpha (LDL) and Beta (HDL) Lipoprotein concentrations were determined after 8weeks of the dietary regimen. Food intake and weight gain of the obese+NIDDM phenotype was greater than the lean phenotype, increased with the SU diet. The weight gains of lean and obese+NIDDM rats fed the SU+ACB diet were similar to rats of the same phenotype fed the ST diet. Fasting I:G ratios were elevated in Obese+NIDDM and were similar to those of ST fed rats fed the ACB diet. Plasma CHOL and TG were greater on obese+NIDDM rats of both sexes, and ACB was associated with modest decreases in CHOL concentrations in both lean and obese+NIDDM rats. No adverse side effects of the ACB were observed in either phenotype. These results indicate that luminal inhibition of carbohydrate digestion via α-glucoside inhibition was associated with improvements in I:G ratios and in plasma lipid profiles that were similar to those observed with the complex CHO ST diet and may be a safe and useful adjunct in the treatment of NIDDM and other carbohydrate intolerant states.


Obesity, NIDDM, Rats, CHO digestion, ?-glucosidase, and LDL and HDL lipid profiles, NIDDM, non-insulin dependent diabetes, T2DM,Type-2 diabetes mellitus, CS, cooked cornstarch, DRTC, diabetes research training core laboratories, LDL, Low density