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Antifungal activities of Erythrina senegalensis hydroalcoholic extract partitions on the resistant germs responsible for candidiasis in HIV-infected subjects


Pharmacy & Pharmacology International Journal
Ousmane Coulibaly,1,2,3,5 Pegnonsienre Lassina Soro,5 Tidiane Kamagate,4 Chiaye Yapo-Crezoit,2 Yaya Soro,3 Karamoko Ouattara5

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Abstract

Since the mortality rate of candidiasis in HIV-infected subjects is very high, Erythrina senegalensis, an Ivorian medicinal plant, would be an alternative to the problem of patient care. It is therefore a question of evaluating in vitro the antifungal activity of Erythrina senegalensis leaves partitionned extracts on resistant strains of Candida albicans. Methods of double dilution in liquid medium and diffusion in solid medium were used for the antifungal tests carried out on the partitions of Erythrina senegalensis leaves hydroalcoholic extract. Among partitions obtained, the hexane partition was the most active with a MIC of 3.12 mg/ml, an IC50 of 0.95 mg/ml on Candida albicans. With an inhibition diameter of 14 mm, this partition has antifungal activity on strains of Candida albicans resistant to amphotericin B and fluconazole, which are antifungals prescribed to PLHIV suffering from candidiasis. The hexane partition of Erythrina senegalensis therefore has a fungistatic action on resistant strains of Candida albicans. This score could therefore be used as an Improved Traditional Medicine (ITM) in the treatment of fungal infections in HIV-infected subjects.

Keywords

Erythrina, hexane, HIV, candidiasis

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