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Photosensitivity and cholestatic hepatitis: the dermatologist contribution for the diagnosis of erythropoietic protoporphyria


Journal of Dermatology & Cosmetology
Bruna Molozzi,1 Ingrid Reuwsaat Paul,1 Timotio Volnei Dorn,1 Gabriella Di Giunta Funchal,1,3 Gustavo Moreira Amorim1,2

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Abstract

We report a case of erythropoietic protoporphyria (EPP) in a young male adult, who was admitted to the hospital due to abdominal pain and jaundice. Complementary exams showed elevation of liver and canalicular enzymes and choledocholithiasis. The patient also had pronounced photodamaged skin and a history of significant photosensitivity since
childhood. The dermatology team, based on the clinical and histological findings, gave the diagnosis of EPP and treatment with cholestyramine was instituted.

Keywords

photosensitivity, porphyria, heme-biosynthesis, erythropoietic protoporphyria, ferrochelatase, choledocholithiasis

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