Abstract

In the cell nucleus, splicing factors organize as cell structures called speckles when visualized by fluorescence microscopy. Morphology of speckles is transcription and splicing activity-dependent. While most studies on speckles have been performed using cell lines, results using cells present in tissues are not so abundant. Here we present a minireview on those studies supporting the results available on cells in culture.

Keywords

Cell nucleus, fluorescence microscopy, RNPs, speckles, tissue