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Speckles in tissues

MOJ Anatomy & Physiology
Jeniffer Acosta-Cárdenas, Luis F. Jiménez-García, María de Lourdes Segura-Valdez

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In the cell nucleus, splicing factors organize as cell structures called speckles when visualized by fluorescence microscopy. Morphology of speckles is transcription and splicing activity-dependent. While most studies on speckles have been performed using cell lines, results using cells present in tissues are not so abundant. Here we present a minireview on those studies supporting the results available on cells in culture.


Cell nucleus, fluorescence microscopy, RNPs, speckles, tissue