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Efficacy and safety of facial treatments with polio lactic acid. Systematic revision

Journal of Dermatology & Cosmetology
Iris Flores Jiménez,1 Pedro Martínez-Carpio,2 Justo M Alcolea3


Introduction: Poly-L-lactic acid (PLLA) is a synthetic polymer from the family of poly
alpha-hydroxy acids widely used in aesthetic medicine. It induces a controlled inflammatory
reaction to a foreign body, with formation of new collagen; therefore, it is considered not
only a facial filler but also a bioimplant.
The aim of this work is to study the efficacy and safety of PLLA as a facial filler based on
the current literature.
Material and methods: After a systematic review of the Medline database (PubMed),
43 valid articles were obtained. Studies were included: interventional, randomized and
non-randomized clinical trials. In addition to observational, prospective and retrospective
studies, whenever PLLA was injected in the facial area.
Results: The overall efficacy (OE) of PLLA in skin rejuvenation was 93%, in lipodystrophy
74% and in acne scars 68%. The total OE was 78%. Of the patients injected with PLLA,
92.3% had no complications, 5.1% mild complications, 2.4% moderate complications and
only 0.2% severe complications.
Conclusion: PLLA requires a refined technique to perform the treatment, although it
presents varied indications and multiple advantages: prolonged permanence of its results,
high efficacy and adequate safety profile.


Poly-L-lactic acid, PLLA, sculptra, New-Fill, facial filler, skin rejuvenation, lipodystrophy, acne, nodule, granuloma