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Effect of surgical hysteroscopy and PGT-A on pregnancy rates in in vitro fertilization with own eggs


Obstetrics & Gynecology International Journal
Villa-Jiménez C,1 Luján Irastorza JE,2 Galindo-Ibarra JL,1 Durand-Montaño C,2 Ruiz-Saenz DR,1 Vargas-Hernandez VM3

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Abstract

Background: In vitro Fertilization (IVF) is a tool for assisted reproduction used with the aim of increasing pregnancy rates in couples with infertility issues. These procedures may be optimized using techniques for genetical evaluation of the embryo by means of preimplantation genetic testing for aneuploidy (PGT-A) or diagnosis and correction of the uterine cavity such as Hysteroscopy.
Objective: The objective of this study was to evaluate the impact of hysteroscopy in contrast with PGT-A analysis with respect to pregnancy rates on IVF cycles.
Materials and methods: A study was carried out with Mexican patients during 2018-2021. Patients were divided in two groups: Group 1, patients with guarded prognosis for fertilization; Group 2, patients with guarded prognosis for implantation. The couples evaluated were subjected to different methodologies before IVF.
Results: It was found that prior use of PGT-A or Hysteroscopy increase pregnancy rates by 9.4% up to 20.92%. In Group 1 the use of PGT-A/IVF caused a mean pregnancy rate of 77.7%, being favorable the transference of a single embryo. In Group 2, the best combination was Hysteroscopy/IVF with a pregnancy rate of 76.96%.
Conclusion: Both of the methodologies prior to the IVF cycle improve pregnancy rates, being recommendable to carry out a PGT-A in patients with a poor genetic prognosis with the transference of a single embryo. Hysteroscopy is recommended when lesions or infectious processes are detected in the uterine cavity, and two-embryo transference is carried out.

Keywords

In vitro fertilization, hysteroscopy, pregnancy, aneuploidy screening

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