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Biological properties of clerodane-type diterpenes

Journal of Analytical & Pharmaceutical Research
Joyce dos R Lima,1 Emanuelle M Marinho,2 Jane ES Alencar de Menezes,1 Francisco Rogênio S Mendes,1 Antonio W da Silva,1 Maria KA Ferreira,1 Larissa Santos Oliveira,1 Italo Moura Barbosa,1 Emmanuel S Marinho,1 Márcia M Marinho,2 Paulo N Bandeira,2 Hélcio S dos Santos1,3

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Clerodane diterpene is composed of hundreds of isolated substances found in several plant species, especially in the families of Labiatae, Euphobiaceae, and Verbenaceae. This paper presents a review of the structural diversification and pharmacological activities related to clerodane-type diterpene to provide a general understanding of these compounds. The review was based on scientific articles published on clerodams, emphasizing the pharmacological activities: antioxidant, antinociceptive, anti-inflammatory, anticancer, and antimicrobial in a period relationship of the last ten years. The predominant genres in the research were Casearia and Ajuga. The most described biological activities for clerodams in this study, among those evaluated, were anticancer, anti-inflammatory, and antimicrobial. The results presented corroborate the importance of using these diterpenes, isolated from plants, as a source of bioactive substances in a promising strategy to contribute to the development of new therapeutic alternatives.


diterpene, clerodane, biological properties