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Prevalence of peripheral blood natural killer cells ≥12% in women with recurrent implantation failure: study carried out in a private clinic of Mexico City

Obstetrics & Gynecology International Journal
Luján-Irastorza Jesús Estuardo,1 Durand-Montaño Carlosm,1 Hernández-Ramos Roberto,1 Ávila-Pérez Felipe de Jesús,1 Ávila-Rebollar Daniela,1 Silva-Meléndez Jorge,1 García-Cruz Valeria,1 Loof-Esquivel Mónica,1 Beltrán-Tapia José Luis,1 Peñalva-Rosales Samuel Octavio,1 Avilés-Sánchez Abel,1 Vargas-Hernández Víctor Manuel2


Objective: To report the incidence of Natural killer cells peripheral blood (pNK) ≥12% and his relationship with Recurrent Implantation Failure (RIF) in a population of Mexican women.
Methods: Retrospective, cross sectional and observational study that included 74 women with history of RIF, which were subjected to a study to evaluate pNK cell levels in order to avoid complications in future pregnancies. 2 groups were formed: 1) Control and 2) RIF: women with a history of implantation failure and primary infertility (with no history of pregnancies or abortions).
Results: Women in RIF were younger and had higher BMI, compared to the Control. Prevalence of patients with pNK cells ≥12% was statistically higher in RIF than in Control (66.6% vs 20%). RIF showed a significative increase of pNK≥1 cell concentration, compared to Control (12.9±4.6 vs 9.5±0.6, p=0.00). When only women with results of pNK ≥12% were evaluated, RIF showed a level numerically higher than that of the Control (16±1.8 vs 13.5±0.8).
Conclusion: RIF may be the result of increased pNK concentrations and as observed in this study, slightly more than 60% of the Mexican population could be susceptible to abortions.


recurrent implantation failure, natural killers, embryo, immunological, delivery