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Cannabidiol self-administration improves general health and symptom scores

International Journal of Complementary & Alternative Medicine
Robert Kaufmann,1 Amber Harris Bozer,2 Keith Aqua,3 Jeff Lombardo4

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Introduction: Self-medication of cannabidiol (CBD) products is exponentially increasing, and there is an indispensable need for a concomitant increase in experimental investigations to facilitate evidence-based applications. In this study, we present the impact of CBD self-administration on the general health and symptoms over four weeks in 839 individuals self-medicating with CBD products for a range of symptoms. 

Methods: Participants that have self-administrated CBD for at least 30days were recruited for the study. Twelve CBD companies provided products for administration over a four-week time-period. Using a digital app, participants provided demographic information and medical history information, and they rated their symptoms and general health prior to and after CBD administration each week. 

Results: The top two reported primary reasons for use were pain and mental health, which together accounted for more than half of the sample. Participants using nano-treated product used less product compared to participants using non-nano-treated product. Repeated measures ANOVAs over the four weeks indicated that both general health scores and symptom scores were significantly higher post-CBD administration for each weekly measure. The effects were not due to a particular brand, composition, or type of CBD.

Conclusions: Individuals self-medicating with CBD demonstrated significant improvements in general health and symptoms and, because of these improvements, reduced their reliance on over the counter and prescription medications. 


cannabidiol, 5-HT1A receptor, G-protein-coupled, full-spectrum, broad-spectrum, alertness, energy, fatigue, and performance, CAAF, arthritis, fibromyalgia, inflammation