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Modulating antibacterial activity against multidrugresistant Escherichia coli and Staphylococcus aureus of the flavonoid pectolinarin isolated from Lantana camara leaves


Journal of Analytical & Pharmaceutical Research
Maria Regivânia Xavier,1 Aluísio Marques da Fonseca,6 Beatriz Gonçalves Cruz,1 Antonia Mayara dos Santos Mendes,2 Larissa Santos Oliveira,1 Paulo Nogueira Bandeira,3 Regilany Paulo Colares,2 Raimundo Braz-Filho,5 Emmanuel Silva Marinho,6 Thiago Sampaio Freitas,1 Henrique Douglas Melo Coutinho,1 Alexandre Magno Rodrigues Teixeira,1 Hélcio Silva dos Santos1,3

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Abstract

The antibiotic potentiating activity against standard and multidrug-resistant Escherichia coli and Staphylococcus aureus bacterial strains of the natural compound 5”-O-α-Lraminopyranosyl-1’-β-D-glycopyranosyl-4’,6-dimethoxyflavone (pectolinarin) isolated from L. camara leaves was evaluated. Tests for antibacterial activity of the pure natural substance and analysis of the potentiation of antibacterial activity of pectolinarin associated with antibiotics were carried out against standard and multiresistant bacterial strains of Escherichia coli and Staphylococcus aureus by microdilution. Pectolinarin, when combined with the antibiotic gentamicin, showed synergism, potentiating growth inhibition against Gram-positive S. aureus strains. The pectolinarin flavonoid when combined with the gentamicin antibiotic potentiated its action Gram-positive S. aureus bacteria. Moreover, an antagonistic effect was observed when the pectolinarin was combined with the penicillin antibiotic against the multiresistant S. aureus 358 strain. This research suggests that pectolinarin is a compound with potential application as an antibacterial drug.

Keywords

: flavonoid, Lantana camara, antibacterial activity

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