The preventive effect of Taurine in early stage of colon chemical carcinogenesis
- International Journal of Complementary & Alternative Medicine
Daniela Hartmann Jornada,1 Diego Eidy Chiba,1 Cauê Benito Scarim,1 Cleverton Roberto de Andrade,2 Edmo Atique Gabriel,3 Chung Man Chin1,3
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Colorectal cancer is one of the most common types of cancer in the world. The aberrant crypts foci are the first dysplastic alterations observed in colons in animal models and in human beings. Taurine is the most abundant semi-essential β-amino acid in mammals and is reported to have a broad anti-inflammatory and antioxidant activity. The purpose of this work was to demonstrate the protective effect of taurine in colon cancer model using the 1,2-dimethylhydrazine (DMH) as a pro-carcinogen agent. For this, the induction of carcinogenesis processes in the Wistar male rats were obtained by the administration of DMH (40mg/kg/day, subcutaneous, twice a week) for two weeks. On the day following the induction, the animals started receiving the taurine (gavage, 100mg/kg/day) for 15 days. Then, the colon was removed, opened longitudinally and ACF (aberrant crypt foci), AC (aberrant crypts) and multiplicity (ACF/AC) were evaluated. The results showed that taurine promoted the decrease of multiplicity of the crypts in the proximal colon (59%) when compared to the non-treated group. The data point to a chemopreventive action of taurine in the promotion of colon cancer in early stage, mainly in the proximal portion which justify further studies to clarify the mechanisms and therapeutic uses.
Jornada DH, Chiba DE, Scarim CB, et al. The preventive effect of Taurine in early stage of colon chemical carcinogenesis. Int J Complement Alt Med. 2021;14(6):242–244.