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Effect of dried ginger water extract on hypertriglyceridemia induced acute pancreatitis in rats


Pharmacy & Pharmacology International Journal
Pratap K Khunti,1 Samir Rabadiya,2 Jalpa Sanandiya,1 Sachin Parmar1

Abstract

Background/objectives: Acute pancreatitis (AP) is characterized by tissue edema, acinar necrosis, hemorrhage, and fat necrosis, as well as inflammation and perivascular infiltration in the pancreas. Serum triglyceride levels more than 1000 mg/dl are accountable for AP. Ginger extract has been reported to reduce the triglyceride level in diabetic rats. This study is aimed to determine the effect of ginger water extract on AP in rats.
Methods: Hypertriglyceridemic-AP was induced by poloxamer 407 (0.7 gm/kg) in Wistar rats. The treatment of ginger water extract was given in two groups with doses of 200 and 400 mg/kg in the rats. The effect of ginger water extract on serum blood glucose, triglyceride, and lipoprotein profile was estimated to access its lipid-lowering properties. The effect of ginger water extract on lipid peroxidation, superoxide dismutase, catalase, and glutathione was also studied.
Results: Ginger extract showed significantly reduced blood glucose, triglyceride, total cholesterol, α-amylase, and increased good cholesterol levels compared to the disease control group that indicated beneficial lipid-lowering properties. Furthermore, ginger water extract was also significantly reduced lipid peroxidation and enhanced superoxide dismutase, catalase, and glutathione levels as compared with the disease control group.
Conclusion: In conclusion, the ameliorative effect of ginger extract against poloxamer 407 induced HTG-AP. Demonstrated lipid-lowering and antioxidant properties of ginger extract. The present study, showed protective effect of ginger against Acute Pancreatitis in rats.

Keywords

acute pancreatitis, hypertriglyceridemia, poloxamer-407, ginger extract

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