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Synthesis, characterization and antioxidant activities of some novel oxime derivatives


Pharmacy & Pharmacology International Journal
Tevfik Ozen,1 Aysun Bal,2 Saim Topcu,2 Murat Tas3

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Abstract

In this study, nine novel compounds were synthesized in the reaction of ω-chloroisonitrosoacetophenone with 2-chloro-4-methylaniline, 2-chloro-5-methylaniline, 2-chloro-6-methylaniline, 3-chloro-2-methylaniline, 4-chloro-3-methylaniline, 5-chloro2-methylaniline, 2,3-dichloroaniline, 2,4-dichloroaniline and 3,5-dichloroaniline resulting for C1-C9, respectively. Compounds C1, C4-C7 and C9 were handled in single crystalline forms, which the structures were also investigated by X-ray single crystal analysis. Compounds were evaluated for their nonenzymatic lipid peroxidation inhibition, antioxidant and antiradical activities and compared with standard agents at 5, 50, and 100μM concentrations. Compounds are exhibited good antioxidant activities and lipid peroxidation compared to standards (BHA, TBHQ, BHT and trolox). Due to the best of our knowledge for novel oxime compounds, this study is the first report of promising antioxidants to scavenge oxidative stress conditions.

Keywords

oximes, carbonyl-oxime, amide-oxime, amido-carbonyl oxime, antioxidant activity, lipid peroxidation inhibition

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