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Association of ITGB3 gene polymorphisms with the risk of developing fetal growth restriction syndrome


MOJ Women's Health
Aslonova MJ,1 Ikhtiyarova GA,1 Mavlyanova NN2

Abstract

The article presents a molecular genetic study of the ITGB3 gene polymorphism in pregnant women with fetal growth restriction syndrome.

Purpose:Assessment of the detectability of the association of the ITGB3 gene polymorphism in women with physiological pregnancy and fetal growth restriction syndrome in the uzbek population of the Bukhara region.

Materials and methods:80 pregnant women were examined during gestation from 8-36 weeks: 40 pregnant women with fetal growth restriction syndrome and 40 women with physiological pregnancy, hospitalized in the department of pathology of pregnant women in the Bukhara city maternity hospital in the city of Bukhara.

Conclusion:The study showed that the functionally unfavorable allele C and the association of the T / C genotype polymorphism of the ITGB3 gene polymorphism can be a determinant of an increased risk of developing FGRS in Uzbekistan (χ2 <0.47; P> 0.05).

Keywords

fetal growth restriction syndrome, endothelial system gene, ITGB3 gene

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