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Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review

Journal of Analytical & Pharmaceutical Research
Ratan Kumari, Nikhila Shekhar, Sakshi Tyagi, Ajit Kumar Thakur


Mitochondrial dysfunction is estimated to be the primary reason involved in different types of neurodegenerative disorders as mitochondria is suggested to be important in the production of reactive oxygen species. Recently, several evidences have emerged out for impaired mitochondrial structures and functions viz. shape, size, fission-fusion, distribution, movement etc. in neurodegenerative diseases especially with Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Therefore, apart from looking neurodegenerative diseases on the whole, a detailed understanding of the functioning of mitochondria and their role in degeneration would pave new options for the therapy of agerelated neurodegenerative diseases.


mitochondrial dysfunction, neurodegenerative disorders, parkinson’s disease, huntington’s disease, and alzheimer’s disease