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Treatment dilemma of a depressed patient with metabolic syndrome


Background: Depression affects around 121 million people world wide according to the world health organization (WHO) and is the second leading cause of disability globally. Metabolic syndrome is defined as a combination of conditions that predispose individuals to several diseases, mainly cardiovascular diseases. The association between metabolic syndrome and depression represents a major social issue for its increasing prevalence. However, proper treatment strategies for patients who have the two overlapping conditions are not yet established
Case report: We report a challenging but successful treatment strategy of a 60 year old male, with metabolic syndrome, diagnosed with depression
Aim: The aim of the report is to highlight the need of developing evidence based treatment strategies for patients with depression overlapping with metabolic syndrome.
Conclusion: Treating patients with depression and metabolic syndrome requires a multidisciplinary team, and cautious decisions as to which antidepressant to start in order to avoid deterioration in their comorbidities. More research is needed in this field as both metabolic syndrome and depression are increasing in prevalence and are among the leading causes of burden to the healthcare system.


depression, metabolic syndrome, antidepressant, psychopharmacology, anxiety