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Good pasture’s syndrome diagnosed in postpartum period: acute kidney injury severe enough to warrant renal transplant


International Journal of Pregnancy & Child Birth
Snigdha Rao Veeramalla,1 Aashima Arora,1 Geetika Thakur,1 Raja Ramachandran,2 Shiv Soni3

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Abstract

Objective: Goodpasture’s syndrome (GPS) is the association of pulmonary haemorrhage with acute kidney injury (AKI) resulting from injury by auto-antibodies. Its de novo occurrence in pregnancy is extremely rare with only few cases reported. High risk of mortality and lack of consensus in treatment warrants its reporting.

Case report: A 24 year old primigravida, with no history suggestive of renal disease, presented to us in her third trimester with anuria. She was initially managed as sepsis or preeclampsia related AKI. However, even after delivery there was no improvement in kidney function with hemodialysis and she developed hemoptysis. Renal biopsy made a diagnosis of Anti-Glomerular Basement Membrane disease. With careful multi-disciplinary treatment, she delivered a live born baby and was discharged under stable condition on hemodialysis, currently awaiting a kidney transplant.

Conclusion: This case highlights that the current management for GPS should be revised to improve the outcome of AKI. Also, it determines how important it is for obstetricians to consider whether a pregnancy should be terminated to improve the outcome of AKI in pregnant patients with GPS.

Keywords

acute kidney injury, goodpature’s syndrome, renal transplant, anti-glomerular basement membrane disease, hemodialysis

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